Customized therapies

Silicate-substituted calcium phosphate + MSC ± EC subcutaneous and intramuscular insertion in nude mice.

Human mesenchymal stem cells were loaded into a a silicate-substituted calcium phosphate (SiCaP) scaffold and then ectopically implanted in immune-depressed mice. We observed bone formation and osteoids composed of host cells. The addition of endothelial cells (EC) in the scaffolds did not stimulate blood vessel ingrowth and resulted in a lower level of osteogenesis (refer 1).

Alginate-based hydrogel

We have demonstrated the capacity of this biomaterial to increase the viability of the transplanted cells (MSC and EC) and to stimulate blood vessel ingrowth (subcutaneous insertion in immunosuppressed mice/ re 3) and to rebuild bone (bone lesion repair, rat cleft plate model)..

Poly-caprolactone/hydroxyapatite electrospun honeycomb scaffold associated with mesenchymal stem cells inserted in a rat calvarial defect model

We have demonstrated, in vivo, the osteo-conduction and osteo-induction properties of the scaffolds. The scaffolds promote bone regeneration and the addition of mesenchymal stem cells further increase bone formation and mineral density.